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VRTX$502.70 −0.16%+ Alert
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● 10 Oct · US closed · scored 20:02
● Sat 10 Oct 2026/US closed · opens Mon 14:30 BST/150 names scored today/last score 14:36 BSTResearch, not advice · every call is published at Proof

VRTX

Vertex Pharmaceuticals Inc
$502.70 · −0.16% vs $503.50 close · scored 20:02 · stale
Decision brief
NEUTRAL · 50/100
What changed
No prior comparable read.
Evidence is stale — treat this read cautiously.
What would change the view
composite leaves the neutral band · confidence deteriorates materially from 50/100
For the read
No strong confirming evidence isolated.
Against / uncertainty
signal stability is low
The read
Neutral, moderately evidenced, but price is moving the other way.
−100 bearish0bullish +100
+3.1 composite+13.2 vs a week ago
Evidence
50 / 100 · top 62% today
2,094 contracts · quality 77 · stability 0.00
neutral · +0.46% · n=12,762
01

Why it’s +3

Method
What traded today · weight 62%
+5.2 pts
1,134 calls · 54.2%960 puts
bias +8.3 × 0.62
What’s on the books · weight 38%
−2.0 pts
5,434 call OI · 47.3%6,044 put OI
bias −5.3 × 0.38
Equals
+3.1
72% of the score comes from today’s volume, 28% from open interest. Disagree with either? See the method.
02

What changed: 43 days of tape against price

14d43d90d365d · Reader
tape composite (bars)— price◆ big one-day moves30d: price −7.95% · tape +8.9 · corr -0.01
◆ −59.8 in a day● peak +41▼ low −42.908-2609-0209-0909-1609-2309-3010-10$558$503

Plain English: Over 30 days, price has fallen 7.95% while the tape has firmed 8.9 points. The two are drifting apart.

03

Should you trust it?

note
Some evidence, not a lot
confidence 50 (38th pct) · quality 77 · 2,094 contracts
note
Jumpy
0.00 vs 7-day rolling · choppiness 92
note
Neutral reads make no call
neutral · balanced · low liquidity → +0.46% avg, n=12,762
note
No reliable lead
enough history exists, but no tape/price lead clears the reliability threshold (r=0.00, n=43)
note
Stretched vs its own history
today’s tape sits high relative to price
against
Our record on VRTX is poor
20% hit rate on 246 closed calls · payoff 0.48×
04

Where the positions sit

calls tradedstrikeputs traded
$527.5
$525
$522.5
$520
$517.5
$515
$512.5
$510
$507.5
$505
$502.5
$500
WALL · OI 1,487
$497.5
$495
$492.5
$490
$487.5
$485
$480
Spot $502.70 highlighted. The $500 strike holds the most open interest (the “wall”, 1,487). Near-dated expiry in the mix, so OI is noisier.
05

Our record on VRTX

Proof
20%
hit rate · 246 closed
0.48×
payoff
−0.24%
avg return
6 Oct · 4h
$502.70 → $502.70
+0.00%flat
3 Oct · 4h
$504.73 → $504.73
+0.00%flat
2 Oct · 4h
$511.00 → $511.00
+0.00%flat
2 Oct · 4h
$506.74 → $506.74
+0.00%flat

One rule everywhere: a move of 0.05% or less is flat, and flat is not a hit. That is the same rule Proof uses; 124 of these 246 calls were flat.

06

Catalysts & context

EPS surprise · last 4 quarters
+3.12%Q3 ’25
−2.79%Q4 ’25
+1.60%Q1 ’26
−2.11%Q2 ’26
Street Buy-leaningNext report — P/E 29.79 · fwd 25.19Beta 0.282 52w $400.74–$560.25IV rank —
Vertex Pharmaceuticals Inc · Biotechnology
Neutral, moderately evidenced. Price is moving the other way.
−100 bearish0bullish +100
+3.1evidence 50
neutral · +0.46% · n=12,762
Why it’s +3
+5.2 volume · 54% calls−2.0 OI · 47% calls
43 days · tape bars, price line
◆ −59.808-2609-0209-0909-1609-2309-3010-10$558$503
Price −7.95%, tape +8.9 over 30 days. The two are drifting apart.
Should you trust it?
noteSome evidence, not a lot
confidence 50 (38th pct) · quality 77 · 2,094 contracts
noteJumpy
0.00 vs 7-day rolling · choppiness 92
noteNeutral reads make no call
neutral · balanced · low liquidity → +0.46% avg, n=12,762
noteNo reliable lead
enough history exists, but no tape/price lead clears the reliability threshold (r=0.00, n=43)
Ask about VRTX
Why did the score rise from −28 to +3 this week?
It was mostly one day. The composite was −28.2 on 30 Sep, then rose to +8.9 on 1 Oct as the price moved from $546.12 to $522.81. It’s at +3.1 now.

Today’s +3.1 breaks down as +5.2 from volume and −2.0 from open interest. I can’t split past days the same way: the stored history keeps call/put volume but not open interest for past days.
tape_history · 44 ptsstock_scores · 20:02method · 62/38
Ask
Explain the $500 wallCompare VRTX vs PURRAlert me before earnings